New insights into mechanisms regulating gene expression in embryonic stem cells
Embryonic stem cells have a unique ability to form all the cell and tissue types of an adult human body. The mechanisms that control this ability have been the target of active research, as stem cells are expected to be an important tool in future medicine. The research results of the research groups of Lund and Lahesmaa have been reported in the Stem Cell Reports journal. - Our results provide new insights into the mechanisms of how POLR3G gene regulates stem cell state, which in turn sheds light on the complex mechanisms with which human embryonic stem cells both self-renew and maintain the ability to differentiate. The results point to indirect genomic regulatory mechanisms which are important for embryonic stem cells and maintain gene expression, say Riikka Lund and Riitta Lahesmaa. Stem cell research is one of the central research areas of modern medicine. The current and most important applications of stem cell research are related to disease diagnostics and ...